Polymeric nanoparticles - Introduction, types, advantages, disadvantages and method of preparation/synthesis
Polymeric nanoparticles, what is polymeric nanoparticles, definition of nanoparticles, method of synthesis/preparation of nanoparticles, advantages and disadvantages of nanoparticles. Introduction/definition They are solid colloidal particles ranging in size from 10 to 1000 nm (1μm). Drug may be dissolved, entrapped, encapsulated or attached to a nanoparticle matrix. Because these systems have very high surfac areas, drugs may also be adsorbed on their surface. Polymer-based nanoparticles effectively carry drugs, proteins and DNA to target cells and organs. Their nanometer-size promotes effective permeation through cell membranes and stability in the blood stream. Types of Polymeric nanoparticles 1. Nanospheres 2. Nanocapsules Nanocapsules : They are systems in which the drug is confined to a cavity surrounded by a unique polymer membrane. Nanospheres : They are the matrix system in which the drug is physically and uniformly dispersed. Polymer used in preparation: Natural hydroph...